David M. Shepherd MD PC

["DMC Harper University Hospital", "DMC Sinai-Grace Hospital", "Henry Ford Providence Southfield Hospital"]

Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC. Salio, M., Shepherd, D., Dunbar, P. R., Palmowski, M., Murphy, K., Wu, L., Cerundolo, V. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Poulton, L. D., Smyth, M. J., Hawke, C. G., Silveira, P., Shepherd, D., Naidenko, O. V., Godfrey, D. I., Baxter, A. G. A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response. Dunbar, P. R., Smith, C. L., Chao, D., Salio, M., Shepherd, D., Mirza, F., Lipp, M., Lanzavecchia, A., Sallusto, F., Evans, A., Russell-Jones, R., Harris, A. L., Cerundolo, V. Targeted deletion of the aryl hydrocarbon receptor in dendritic cells prevents thymic atrophy in response to dioxin Celine A. Beamer, Joanna M. Kreitinger, Shelby L. Cole, David M. Shepherd Dendritic Cell Assays. Joanna M. Kreitinger, David M. Shepherd Environmental Immunology: Lessons Learned from Exposure to a Select Panel of Immunotoxicants. Joanna M. Kreitinger, Celine A. Beamer, David M. Shepherd Acute Exposure to Crystalline Silica Reduces Macrophage Activation in Response to Bacterial Lipoproteins Gillian Beamer, Benjamin P. Seaver, Forrest Jessop, David M. Shepherd, Celine A. Beamer In vitro Exposure to the Herbicide Atrazine Inhibits T Cell Activation, Proliferation, and Cytokine Production and Significantly Increases the Frequency of Foxp3+ Regulatory T Cells Lindsay E. Thueson, Tiffany R. Emmons, Dianna L. Browning, Joanna M. Kreitinger, David M. Shepherd, Scott A. Wetzel Role of the aryl hydrocarbon receptor (AhR) in lung inflammation Celine A. Beamer, David M. Shepherd Inhibition of TLR Ligand- and Interferon Gamma-Induced Murine Microglial Activation by Panax Notoginseng Celine A. Beamer, David M. Shepherd Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation, but not fibrosis Celine A. Beamer, Benjamin P. Seaver, David M. Shepherd Dietary Ligands of the Aryl Hydrocarbon Receptor Induce Anti-Inflammatory and Immunoregulatory Effects on Murine Dendritic Cells Jenna M. Benson, David M. Shepherd Aryl Hydrocarbon Receptor Activation by TCDD Reduces Inflammation Associated with Crohn's Disease Jenna M. Benson, David M. Shepherd Anti-inflammatory effects of natural product formulations on murine dendritic cells. Andrea K. Miller, Jenna M. Benson, Dave N. Muanza, Jerry R. Smith, David M. Shepherd Consequences of AhR Activation in Steady-State Dendritic Cells Tom Simones, David M. Shepherd Functional and phenotypic effects of AhR activation in inflammatory dendritic cells. Jaishree Bankoti, Ben Rase, Tom Simones, David M. Shepherd Effects of TCDD on the fate of naive dendritic cells Jaishree Bankoti, Andrea Burnett, Severine Navarro, Andrea K. Miller, Ben Rase, David M. Shepherd Echinacea purpurea extracts modulate murine dendritic cell fate and function. Jenna M. Benson, Amanda J. Pokorny, Ava Rhule, Cynthia A. Wenner, Vamsikrishna Kandhi, Nadja B. Cech, David M. Shepherd Toll-like receptor ligand-induced activation of murine DC2.4 cells is attenuated by Panax notoginseng. Ava Rhule, Benjamin Rase, Jerry R. Smith, David M. Shepherd Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. Ava Rhule, Severine Navarro, Jerry R. Smith, David M. Shepherd Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. Castle J. Funatake, Erica A. Dearstyne, Linda B. Steppan, David M. Shepherd, Elena S. Spanjaard, Ann Marshak-Rothstein, Nancy I. Kerkvliet CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis Mark Leid, Jane E. Ishmael, Dorina Avram, David M. Shepherd, Valérie Fraulob, Pascal Dollé Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression Thanaset Senawong, Valerie J. Peterson, Dorina Avram, David M. Shepherd, Roy A. Frye, Saverio Minucci, Mark Leid T Lymphocytes Are Direct, Aryl Hydrocarbon Receptor (AhR)-Dependent Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): AhR Expression in Both CD4+ and CD8+ T Cells Is Necessary for Full Suppression of a Cytotoxic T Lymphocyte Response by TCDD Nancy I. Kerkvliet, David M. Shepherd, L Baecher-Steppan Anti-CD40 Treatment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-exposed C57Bl/6 mice induces activation of antigen presenting cells yet fails to overcome TCDD-induced suppression of allograft immunity. David M. Shepherd, Linda B. Steppan, Olaf R. Hedstrom, Nancy I. Kerkvliet The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11.10 transgenic CD4+ T cells in adoptively transferred mice David M. Shepherd, Erica A. Dearstyne, Nancy I. Kerkvliet Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation. David M. Shepherd, Nancy I. Kerkvliet Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Nancy I. Kerkvliet, L Baecher-Steppan, David M. Shepherd, J A Oughton, Beth A. Vorderstrasse, G K DeKrey Signaling events during helper T cell-dependent B cell activation. I. Analysis of the signal transduction pathways triggered by activated helper T cell in resting B cells. Lisa S. Marshall, David M. Shepherd, Jeffrey A. Ledbetter, Alejandro Aruffo, Randolph J. Noelle In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. Teresa M. Foy, David M. Shepherd, Fiona H. Durie, Alejandro Aruffo, Jeffrey A. Ledbetter, Randolph J. Noelle In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. A. J. M. Van Den Eertwegh, Randolph J. Noelle, Meenakshi Roy, David M. Shepherd, Alejandro Aruffo, Jeffrey A. Ledbetter, Wim J. A. Boersma, Eric Claassen Immunotoxicology of cadmium and mercury on B-lymphocytes — I. Effects on lymphocyte function John R. Daum, David M. Shepherd, Randolph J. Noelle Cognate interaction between T helper cells and B cells. VII. Role of contact and lymphokines in the expression of germ-line and mature gamma 1 transcripts. Randolph J. Noelle, David M. Shepherd, H P Fell A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells Randolph J. Noelle, Meenakshi Roy, David M. Shepherd, Ivan Stamenkovic, Jeffrey A. Ledbetter, Alejandro Aruffo Cognate interactions between helper T cells and B cells. V. Reconstitution of T helper cell function using purified plasma membranes from activated Th1 and Th2 T helper cells and lymphokines. Randolph J. Noelle, J Daum, W C Bartlett, J McCann, David M. Shepherd Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells. W C Bartlett, J McCann, David M. Shepherd, Meenakshi Roy, Randolph J. Noelle